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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: Neuropilin and tolloid-like 2 (NETO2) is closely related to tumorigenesis.invasion by downregulating the levels of calcium ions (Ca2+) and the expression of key genesinvolved in the calcium signaling pathway.Importantly, pharmacological inhibition of CaMKII/CREB activity with the CaMKII inhibitor KN93 suppressedNETO2-induced proliferation and melanoma metastasis.

Keywords： melanoma     neuropilin and tolloid-like 2     Ca2+/CaMKII signaling pathway    

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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathwayDisruption of the Nrf2 axis abolished the effects of apigenin on the alleviation of oxidative stress

Keywords： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: Mechanistically, FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of the mTOR signalingpathway.Furthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6Altogether, our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signalingpathway.

Keywords： FRMD6     lung cancer     mTOR pathway    

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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 68-78 doi: 10.1007/s11684-014-0308-4

Abstract: The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulationThis review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs

Keywords： planar cell polarity     neural tube defects     rare mutations    

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: -catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and diseaseobserved and their exact functions approached, thus ensuring the most complicated understanding of this pathwayIn hepatocellular carcinoma (HCC), with a deeply understanding of this pathway, more and more genes which-catenin signaling pathway has recently been identified and their exact roles in HCC pursued.In this review, we will focus on a mostly updated understanding of this pathway and its observed role

Keywords： interacting     complicated understanding     embryogenesis     activation     organism development    

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Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 534-548 doi: 10.1007/s11684-022-0953-y

Abstract: that MenSCs improved AIH, mainly by apoptosis and c-Jun N-terminal kinase/mitogen-activated protein signalingAML12 co-culture system and JNK inhibitor (SP600125) were used to verify the JNK/MAPK and apoptosis signaling

Keywords： autoimmune hepatitis (AIH)     concanavalin A (Con A)     human menstrual blood-derived stem cells (MenSCs)     apoptosis     mitogen-activated protein kinase (MAPK)    

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Caveolin proteins: a molecular insight into disease

Hongli Yin,Tianyi Liu,Ying Zhang,Baofeng Yang

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 397-404 doi: 10.1007/s11684-016-0483-6

Abstract:

Caveolae are a kind of specific cystic structures of lipid rafts in the cytoplasmic membrane and are rich in cholesterol and sphingolipids. In recent years, many researchers have found that both caveolins and caveolae play a role in the development of various human diseases, including coronary heart disease, hypertension, and nervous system disorders. The specific mechanisms by which caveolins induce diseases have been a topic of interest. However, a number of detailed molecular mechanisms remain poorly understood. This article focuses on the relationship between caveolin proteins and human diseases and reviews the molecular mechanisms of caveolins in disease networks.

Keywords： caveolin     caveolae     microRNA     disease     signaling pathway     heart     tumor    

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Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 33-39 doi: 10.1007/s11684-011-0114-1

Abstract: underlying migration of MSCs into the injured tissue are still not fully understood, although multiple signalingThis review will briefly summarize the regulatory facors and signaling transduction pathways involved

Keywords： mesenchymal stem cells     migration     molecular mechanisms     signaling pathway    

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Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 46-56 doi: 10.1007/s11684-015-0375-1

Abstract: The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expressionThis review article is focused on triterpenoids that activate Nrf2, and their potential for reducing

Keywords： oxidative stress     Nrf2     triterpenoids     sickle cell disease     vaso-occlusion     CDDO-Me    

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Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 362-372 doi: 10.15302/J-FASE-2018206

Abstract: related to biological oxidation, and can reduce oligopeptide absorption capacity by regulating Hippo signalingpathway.intake of beef and fish proteins had no significant effect on PEPT1 expression, they altered several signaling

Keywords： Hippo signaling pathway     meat protein     PEPT1     proteome analysis     rat jejunum    

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Kinetics of pozzolanic reaction for preparation of flue gas desulfurizer from fly ash and Ca(OH)2

WANG Jingang, HU Jinbang, WANG Daobin, DUAN Zhenya

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 3,   Pages 266-270 doi: 10.1007/s11705-007-0048-y

Abstract: kinetic model of the pozzolanic reaction for the preparation of flue gas desulfurizers from fly ash and Ca

Keywords： comparison     calculated     pozzolanic reaction     precision     preparation    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2

Keywords： palmitate     characteristic     study     plasma     resistance    

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Laboratory study on high-temperature adsorption of HCl by dry-injection of Ca(OH)

Junjun TAN,Guohua YANG,Jingqiao MAO,Huichao DAI

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6,   Pages 863-870 doi: 10.1007/s11783-013-0618-9

Abstract: experiments were conducted in a dual-layer granular bed filter, at gas temperatures of 500°C–700°C and (Ca)/ (Cl)molar ratios of 1.0–5.0 using the silver nitrate titration method by dry adsorbent powders Ca(of HCl and utilization efficiency of Calcium were studied, by varying relevant factors including (Caexperimental results revealed that 600°C may be the optimum temperature for HCl adsorption when optimum (Capressure was more effective, and the HCl adsorption efficiency could rapidly reach over 90% with (Ca

Keywords： acid gas HCl     Ca(OH)2     dry adsorption     high temperature     dual-layer granular bed filter    

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Pathway of the ozonation of 2,4,6-trichlorophenol in aqueous solution

PI Yunzheng, WANG Jianlong

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 2,   Pages 179-183 doi: 10.1007/s11783-007-0031-3

Abstract: The reaction mechanism and pathway of the ozonation of 2,4,6-trichlorophenol (2,4,6-TCP) in aqueous solutionThe results showed that when there was no scavenger, the removal efficiency of 0.1 mmol/L 2,4,6-TCP couldThe reaction of molecular ozone with 2,4,6-TCP resulted in the formation of HO.Therefore, 2,4,6-TCP was degraded to formic acid and oxalic acid by ozone and OH° radicals together.Two reaction pathways of the degradation of 2,4,6-TCP by ozone and O/OH° were proposed in this study.
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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation via TGFBR2.AKT and TGFBR2 inhibition resulted in the reversal of the GDF15-induced expression of UGT1A, indicatingthat TGFBR2-AKT pathway-dependent metabolic pathways were involved in the resistance of ESCC cells to

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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Title Author Date Type Operation

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Journal Article

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Journal Article

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Journal Article

Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway

Journal Article

Caveolin proteins: a molecular insight into disease

Hongli Yin,Tianyi Liu,Ying Zhang,Baofeng Yang

Journal Article

Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms

Li LI, Jianxin JIANG

Journal Article

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Journal Article

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Journal Article

Kinetics of pozzolanic reaction for preparation of flue gas desulfurizer from fly ash and Ca(OH)2

WANG Jingang, HU Jinbang, WANG Daobin, DUAN Zhenya

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Laboratory study on high-temperature adsorption of HCl by dry-injection of Ca(OH)

Junjun TAN,Guohua YANG,Jingqiao MAO,Huichao DAI

Journal Article

Pathway of the ozonation of 2,4,6-trichlorophenol in aqueous solution

PI Yunzheng, WANG Jianlong

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Journal Article